BDBM50556644 CHEMBL1214274::NSC-45382

SMILES ClC1=C(Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)C(=O)c2ccccc2C1=O

InChI Key InChIKey=QRPKNPKHGNUFGK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50556644   

TargetProteasome subunit beta type-5(Human)
Ege University

Curated by ChEMBL
LigandPNGBDBM50556644(NSC-45382 | CHEMBL1214274)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of chymotrypsin-like activity 20S proteasome beta subunit 5 of human MCF7 cells using fluorogenic substrate Suc-LLVY-AMC after 1 hr by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Ege University

Curated by ChEMBL
LigandPNGBDBM50556644(NSC-45382 | CHEMBL1214274)
Affinity DataIC50: 5.31E+4nMAssay Description:Inhibition of caspase-like activity 20S proteasome beta subunit 1 of human MCF7 cells using fluorogenic substrate Z-LLE-AMC after 1 hr by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Ege University

Curated by ChEMBL
LigandPNGBDBM50556644(NSC-45382 | CHEMBL1214274)
Affinity DataIC50: 2.64E+4nMAssay Description:Inhibition of trypsin-like activity 20S proteasome beta subunit 2 of human MCF7 cells using fluorogenic substrate Boc-LRR-AMC after 1 hr by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTranscription factor 4(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50556644(NSC-45382 | CHEMBL1214274)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of beta catenin/Tcf4 (8 to 30 reisdues) (unknown origin) incubated for 3 hrs by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranscription factor 4(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50556644(NSC-45382 | CHEMBL1214274)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of beta-Catenin/FITC-labeled TCF4 (8 to 30 residues) (unknown origin) protein-protein interaction incubated for 3 hrs by fluorescence pola...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed