BDBM50481947 CHEBI:8416::GNF-Pf-476::PRISTIMERIN::Pristimerine::US11660306, Example Pristimerin::acs.jmedchem.1c00409_ST.332

SMILES [H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(=O)OC

InChI Key InChIKey=JFACETXYABVHFD-UHFFFAOYSA-N

Data  4 KI  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50481947   

TargetReplicase polyprotein 1ab(SARS-CoV)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50481947(CHEBI:8416 | GNF-Pf-476 | Pristimerine | PRISTIMER...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of 3C-like protease of SARS coronavirus assessed as concentration of FRET peptide for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetNuclear receptor subfamily 4 group A member 1(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50481947(CHEBI:8416 | GNF-Pf-476 | Pristimerine | PRISTIMER...)
Affinity DataKd:  960nMAssay Description:Binding affinity to recombinant human N-terminal His-tagged Nur77 LBD (367 to 598 residues) expressed in Escherichia coli BL21(DE3) incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50481947(CHEBI:8416 | GNF-Pf-476 | Pristimerine | PRISTIMER...)
Affinity DataIC50: 5.50E+3nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2022
Entry Details Article
PubMed
TargetMonoglyceride lipase(Rat)
Nanchang University

Curated by ChEMBL
LigandPNGBDBM50481947(CHEBI:8416 | GNF-Pf-476 | Pristimerine | PRISTIMER...)
Affinity DataIC50: 93nMAssay Description:Inhibition of recombinant rat MAGL by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMonoacylglycerol lipase ABHD6(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50481947(CHEBI:8416 | GNF-Pf-476 | Pristimerine | PRISTIMER...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of ABHD6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50481947(CHEBI:8416 | GNF-Pf-476 | Pristimerine | PRISTIMER...)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of 3C-like protease of SARS coronavirus assessed as concentration of FRET peptide for 60 mins by dixon plotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50481947(CHEBI:8416 | GNF-Pf-476 | Pristimerine | PRISTIMER...)
Affinity DataKi:  3.10E+3nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-405](Human)
Cold Spring Harbor Laboratory

US Patent
LigandPNGBDBM50481947(CHEBI:8416 | GNF-Pf-476 | Pristimerine | PRISTIMER...)
Affinity DataKi:  8.00E+3nMAssay Description:Glucose in tail blood was measured using a glucometer (One-Touch Basic; Lifescan, CA). For glucose tolerance tests (GTTs), mice were fasted for 10 ho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 1 [1-321](Human)
Cold Spring Harbor Laboratory

US Patent
LigandPNGBDBM50481947(CHEBI:8416 | GNF-Pf-476 | Pristimerine | PRISTIMER...)
Affinity DataKi:  1.00E+4nMAssay Description:Glucose in tail blood was measured using a glucometer (One-Touch Basic; Lifescan, CA). For glucose tolerance tests (GTTs), mice were fasted for 10 ho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
Go to US Patent