BDBM50327070 1-(2-chloro-4-(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea::1-{2-Chloro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-oxy]phenyl}-3-[3-(trifluoromethyl)phenyl]urea::CHEMBL1254190::D3RKN_20

SMILES Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)c(Cl)c3)c12

InChI Key InChIKey=OCINIHGZWSHFSH-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50327070   

TargetVascular endothelial growth factor receptor 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50327070(1-(2-chloro-4-(5-methyl-5H-pyrrolo[3,2-d]pyrimidin...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50327070(1-(2-chloro-4-(5-methyl-5H-pyrrolo[3,2-d]pyrimidin...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of His-tagged human VEGFR2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50327070(1-(2-chloro-4-(5-methyl-5H-pyrrolo[3,2-d]pyrimidin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of His-tagged human FGFR1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
D3R/Abbott

LigandPNGBDBM50327070(1-(2-chloro-4-(5-methyl-5H-pyrrolo[3,2-d]pyrimidin...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2022More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

LigandPNGBDBM50327070(1-(2-chloro-4-(5-methyl-5H-pyrrolo[3,2-d]pyrimidin...)
Affinity DataKd:  4.20E+3nMAssay Description:D3R2023More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R