BDBM700923 N-(2-((2,5-dichloropyrimidin-4- yl)amino)-6- ethylphenyl)methanesulfonamide::US20240343694, Example 50

SMILES CCc2cccc(Nc1nc(Cl)ncc1Cl)c2NS(C)(=O)=O

InChI Key InChIKey=AWAQPOJKUHZWQC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 700923   

TargetEpidermal growth factor receptor [1-18,20-1210](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700923(N-(2-((2,5-dichloropyrimidin-4- yl)amino)-6- ethyl...)
Affinity DataIC50: 1nMAssay Description:The activity of the compounds of the present invention against EGFR mutant enzymes was measured using the HTRF system purchased from Cisbio as follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-763,'FHEA',764-1210](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700923(N-(2-((2,5-dichloropyrimidin-4- yl)amino)-6- ethyl...)
Affinity DataIC50: 3nMAssay Description:The activity of the compounds of the present invention against EGFR mutant enzymes was measured using the HTRF system purchased from Cisbio as follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700923(N-(2-((2,5-dichloropyrimidin-4- yl)amino)-6- ethyl...)
Affinity DataIC50: 60nMAssay Description:The activity of the compounds of the present invention against HER mutant enzymes was measured using the HTRF system purchased by Cisbio as follows. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent