BDBM651004 12,12,17,18,21-pentafluoro-6- (propan-2-yl)-2-[4-(prop-2- enoyl)piperazin-1-yl]-10,11,12,13- tetrahydro-4H-1,19- (ethanediylidene)pyrido[4,3- f]pyrimido[1,6-h][1,8,10] benzoxadiazacyclotri- decin-4-one::US20240043448, Example 65

SMILES CC(C)c1nccc2CCC(F)(F)COc3ccc(F)c(F)c3-c3nc4n(-c12)c(=O)nc(N1CCN(CC1)C(=O)C=C)c4cc3F

InChI Key InChIKey=VGVOYOGUIRBGHW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 651004   

TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651004(12,12,17,18,21-pentafluoro-6- (propan-2-yl)-2-[4-(...)
Affinity DataIC50: 2.60nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
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