BDBM6346 2-Aminoquinazoline 25::8-cyclopentyl-2-{[4-(morpholin-4-yl)phenyl]amino}quinazolin-7-ol

SMILES Oc1ccc2cnc(Nc3ccc(cc3)N3CCOCC3)nc2c1C1CCCC1

InChI Key InChIKey=PVZBVJXRCNTAAW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6346   

LigandPNGBDBM6346(8-cyclopentyl-2-{[4-(morpholin-4-yl)phenyl]amino}q...)
Affinity DataIC50: 1.94E+3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Naeja Pharmaceutical

LigandPNGBDBM6346(8-cyclopentyl-2-{[4-(morpholin-4-yl)phenyl]amino}q...)
Affinity DataIC50: 180nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Naeja Pharmaceutical

LigandPNGBDBM6346(8-cyclopentyl-2-{[4-(morpholin-4-yl)phenyl]amino}q...)
Affinity DataIC50: 635nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed
LigandPNGBDBM6346(8-cyclopentyl-2-{[4-(morpholin-4-yl)phenyl]amino}q...)
Affinity DataIC50: 3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed