BDBM609381 US11702418, Example 4-3

SMILES CNCc1ccccc1-c1ccc(s1)C(C)Nc1nnc(C)c2cc(OC)c(OC)cc12

InChI Key InChIKey=MAIQECXFWXFWMK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 609381   

TargetSon of sevenless homolog 1 [564-1049]()
Mirati Therapeutics

US Patent
LigandPNGBDBM609381(US11702418, Example 4-3)
Affinity DataIC50: 4.5nMAssay Description:Table 21: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetSon of sevenless homolog 1 [564-1049]()
Mirati Therapeutics

US Patent
LigandPNGBDBM609381(US11702418, Example 4-3)
Affinity DataIC50: 71nMAssay Description:Table 24: This Example illustrates that exemplary compounds of the present invention prevent KRas-mediated GTP nucleotide exchange mediated by SOS1 t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent