BDBM50616939 CHEMBL5434353

SMILES NC(=O)c1cccc(CNC(=O)c2ccc3nc(-c4ccc5cnccc5c4)n(C4CCCC4)c3c2)c1

InChI Key InChIKey=KDAVHUIMGSUDCW-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50616939   

TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616939(CHEMBL5434353)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta by LanthaScreen TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616939(CHEMBL5434353)
Affinity DataIC50: 1.31E+5nMAssay Description:Inhibition of ACVRL1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616939(CHEMBL5434353)
Affinity DataIC50: 1.24E+5nMAssay Description:Inhibition of ACVR1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1A(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616939(CHEMBL5434353)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of BMPR1A (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616939(CHEMBL5434353)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of TGFBR1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616939(CHEMBL5434353)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of BMPR1B (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616939(CHEMBL5434353)
Affinity DataKi:  8nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed