BDBM50598520 CHEMBL5174716::US20240300941, Compound A3

SMILES CN1CCC(CC1)c1ncc(s1)-c1cnc(N)c(OCc2cccc(c2)C#CC(C)(C)O)c1

InChI Key InChIKey=BJNWUKRWOQERPQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50598520   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598520(CHEMBL5174716 | US20240300941, Compound A3)
Affinity DataIC50: 100nMAssay Description:Inhibition of HPK1 (unknown origin) preincubated for 15 mins measured after 90 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598520(CHEMBL5174716 | US20240300941, Compound A3)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HPK1 in human Jurkat E6.1 cells assessed as inhibition of SLP76 phosphorylation treated for 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598520(CHEMBL5174716 | US20240300941, Compound A3)
Affinity DataIC50: 10nMAssay Description:Inhibition of HPK1 (unknown origin) incubated for 15 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598520(CHEMBL5174716 | US20240300941, Compound A3)
Affinity DataIC50: 100nMAssay Description:Inhibition of HPK1 in human Jurkat E6.1 cells assessed as phosphorylation of SLP76 at serine 376 residue incubated for 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598520(CHEMBL5174716 | US20240300941, Compound A3)
Affinity DataIC50: 100nMAssay Description:The buffer used in the enzyme assay contains 5 mM MOPS (pH=7.2), 2.5 mM β-Glycerol Phosphate, 0.4 mM EDTA, 1 mM EGTA, 0.05 mM DTT, 5 mM MgCl2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598520(CHEMBL5174716 | US20240300941, Compound A3)
Affinity DataIC50: 10nMAssay Description:Inhibition of HPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed