BDBM50595424 CHEMBL5172865

SMILES Cn1nc(cc1COc1cccc(c1)[C@@H](NC(=O)O[C@H]1CN2CCC1CC2)c1ccccc1)C(=O)OCCCCNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12

InChI Key InChIKey=YWSIONULMMKTSJ-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50595424   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50595424(CHEMBL5172865)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50595424(CHEMBL5172865)
Affinity DataIC50: 1.21E+5nMAssay Description:Inhibition of human NaV1.5 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50595424(CHEMBL5172865)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CaV1.2 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor(Guinea pig)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50595424(CHEMBL5172865)
Affinity DataIC50: 0.200nMAssay Description:Invivo antagonist activity at muscarinic M3 receptor activity in Dunkin-Hartley guinea pig trachea assessed as inhibition of carbachol induced contra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Guinea pig)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50595424(CHEMBL5172865)
Affinity DataIC50: 0.0794nMAssay Description:Invivo agonist beta2 adrenoceptor activity in Dunkin-Hartley guinea pig trachea assessed as histamine induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50595424(CHEMBL5172865)
Affinity DataKi:  0.00398nMAssay Description:Displacement of 125I-cyanopindolol from human beta2 adrenoceptor expressed in CHO-K1 cell membrane measured after 1 hr by Cheng-prusoff equation anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50595424(CHEMBL5172865)
Affinity DataKi:  0.0631nMAssay Description:Displacement of [3H]-methylscopolamine from human muscarinic M3 receptor expressed in CHO-K1 cell membrane measured after 2 hr by Cheng-prusoff equat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details Article
PubMed