BDBM50551092 CHEMBL4749570

SMILES COc1ccc(OC)c2c1c(OC)cc1c2oc(cc1=O)-c1ccc(cc1)-c1cn(CCOc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)nn1

InChI Key InChIKey=PCEJZZQEYHWWEA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50551092   

TargetCytochrome P450 1B1(Human)
Hunan Agricultural University

Curated by ChEMBL
LigandPNGBDBM50551092(CHEMBL4749570)
Affinity DataIC50: 101nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in baculovirus infected insect cells using 7-ethoxyresorufin as substrate preincubated for 5 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Hunan Agricultural University

Curated by ChEMBL
LigandPNGBDBM50551092(CHEMBL4749570)
Affinity DataIC50: 9.03E+3nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in baculovirus infected insect cells using 7-ethoxyresorufin as substrate preincubated for 5 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
Hunan Agricultural University

Curated by ChEMBL
LigandPNGBDBM50551092(CHEMBL4749570)
Affinity DataIC50: 24nMAssay Description:Potentiation of amphotericin-induced cytotoxicity against human DU-145 cells over expressing CYP1B1 assessed as reversal of CYP1B1 mediated drug resi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed