BDBM50544391 CHEMBL4636189

SMILES O=C(NC(c1ccccc1)c1ccccc1)c1cc(nc2ccccc12)-c1cc2ccccc2o1

InChI Key InChIKey=JNULQPRWYHVXHT-UHFFFAOYSA-N

Data  15 IC50  2 Kd  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50544391   

TargetHistone deacetylase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of HDAC2 (unknown origin) by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of HDAC11 (unknown origin) by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of HDAC10 (unknown origin) by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of HDAC9 (unknown origin) by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of HDAC8 (unknown origin) by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of HDAC7 (unknown origin) by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of HDAC6 (unknown origin) by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of HDAC5 (unknown origin) by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of HDAC4 (unknown origin) by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of HDAC3 (unknown origin) by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataEC50:  5.35E+3nMAssay Description:Activation of N-terminal his-tagged human SIRT6 expressed in Escherichia coli M15 [pREP4] assessed as increase in peptide demyristoylation incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of HDAC1 (unknown origin) by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of SIRT5 (unknown origin) by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of SIRT3 (unknown origin) by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of SIRT2 (unknown origin) by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataIC50: 1.71E+5nMAssay Description:Inhibition of SIRT1 (unknown origin) by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataKd:  5.52E+3nMAssay Description:Binding affinity to N-terminal his-tagged human SIRT6 expressed in Escherichia coli M15 [pREP4] by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataKd:  8.85E+3nMAssay Description:Binding affinity to N-terminal his-tagged human SIRT6 expressed in Escherichia coli M15 [pREP4] by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataEC50:  5.49E+3nMAssay Description:Activation of N-terminal his-tagged human SIRT6 expressed in Escherichia coli M15 [pREP4] assessed as increase in deacetylation activity incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataEC50:  8.91E+3nMAssay Description:Activation of N-terminal his-tagged human SIRT6 expressed in Escherichia coli M15 [pREP4] assessed as increase in deacetylation activity incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed