BDBM50462327 CHEMBL4246749

SMILES CC(C)Cc1ccc(cc1)C(C)c1nc2cc(ccc2n1Cc1ccccc1Cl)-c1ccc(cc1)C(O)=O

InChI Key InChIKey=RBTVLIKFGSTVHT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50462327   

TargetProstaglandin E synthase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50462327(CHEMBL4246749)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell microsomal fractions assessed as reduction in PGE2 production preincubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetArachidonate 5-lipoxygenase-activating protein(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50462327(CHEMBL4246749)
Affinity DataIC50: 40nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50462327(CHEMBL4246749)
Affinity DataIC50: 1.59E+4nMAssay Description:Inhibition of human LTC4 synthase expressed in HEK293 cell microsomes preincubated for 10 mins followed by LTA4-methyl ester addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50462327(CHEMBL4246749)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 incubated for 15 mins prior to prewarming for 30 secs followed by CaCl2+ and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed