BDBM50395923 CHEMBL2164550

SMILES Fc1ccc(nc1)-c1noc(n1)-c1cc(F)cc(c1)C#N

InChI Key InChIKey=RBSPCALDSNXWEP-UHFFFAOYSA-N

Data  4 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50395923   

TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataKd:  9.40nMAssay Description:Binding affinity to mGluR5 in Sprague-Dawley rat striatum after 60 mins by autoradiographic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataKd:  7.20nMAssay Description:Binding affinity to human mGluR5 expressed in HEK293 cell membranes expressing GLAST after 1 hr by scintillation counter in presence of 20 nM MPEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to human mGluR5 expressed in HEK293 cell membranes expressing GLAST after 1 hr by scintillation counter in presence of 10 nM MPEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataKd:  3.80nMAssay Description:Binding affinity to human mGluR5 expressed in HEK293 cell membranes expressing GLAST after 1 hr by scintillation counter in absence of MPEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataIC50: 7.60nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human ERG by IonWorks assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataIC50: 2.60nMAssay Description:Negative allosteric modulation of rat recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracellu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataKd:  2.25nMAssay Description:Binding affinity to human mGluR5 expressed in HEK293 cell membranes expressing GLAST by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataIC50: 26nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of glutamate-stimulated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed