BDBM50389939 CHEMBL1553629

SMILES CCc1c2cc(ccc2[nH]c1C(=O)NCCc3ccc(cc3)N4CCCCC4)Cl

InChI Key InChIKey=AHFZDNYNXFMRFQ-UHFFFAOYSA-N

Data  10 IC50  8 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50389939   

TargetCannabinoid receptor 1(Human)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataEC50:  83nMAssay Description:Positive allosteric modulator activity at human CB1R expressed in CHO cells assessed as enhanced binding of [3H]CP55,940 after 60 mins by liquid scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO-RD-HGA16 cells overexpressing Galpha16 assessed as inhibition of CP55940-stimulated calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataIC50: 158nMAssay Description:Allosteric antagonist activity at N-terminal 3HA-tagged human CB1 receptor expressed in HEK293 cells assessed as reduction in CP55940-stimulated inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataIC50: 1.00E+3nMAssay Description:Allosteric antagonist activity at human CB1 receptor expressed in HEK293 cell membrane assessed as inhibition of CP55940-stimulated [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataIC50: 794nMAssay Description:Allosteric antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells overexpressing Galpha16 assessed as inhibition of CP55940-stimul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataIC50: 0.290nMAssay Description:Positive allosteric modulatory activity at C-terminal GFP-tagged human CB1R expressed in HEK293 cell membrane after 90 mins in presence of [3H]CP5594...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataIC50: 853nMAssay Description:Allosteric antagonist activity at human CB1 receptor by Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataIC50: 853nMAssay Description:Allosteric antagonist activity at human CB1 receptor by Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataIC50: 2nMAssay Description:Negative allosteric modulation of human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940 induced beta arrestin recruitment pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataIC50: 853nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataEC50:  9.10nMAssay Description:Negative allosteric modulator activity at human CB1R expressed in CHO-K1 cells assessed as inhibition of CP55,940-induced beta-arrestin recruitment p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataEC50:  324nMAssay Description:Negative allosteric modulator activity at human CB1R expressed in CHO-K1 cells assessed as effect on CP55,940-induced inhibition of forskolin-induced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataIC50: 1.00E+4nMAssay Description:Allosteric modulation of human recombinant CB2 receptor expressed in HEK293 cells assessed as inhibition of [3H]CP55940 bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataEC50:  140nMAssay Description:Allosteric modulation of human recombinant CB1 receptor expressed in HEK293 cells assessed as stimulation of [3H]CP55940 bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataEC50:  1.06E+4nMAssay Description:Activity at hemagglutinin-tagged human CB1 receptor expressed in HEK293 cells assessed as effect on forskolin-induced cAMP accumulation after 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataEC50:  2.24E+3nMAssay Description:Activity at hemagglutinin-tagged human CB1 receptor expressed in HEK293 cells assessed as effect on forskolin-induced cAMP accumulation in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataEC50:  640nMAssay Description:Activity at hemagglutinin-tagged human CB1 receptor expressed in HEK293 cells assessed as effect on forskolin-induced cAMP accumulation after 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50389939(CHEMBL1553629)
Affinity DataEC50:  2.09E+3nMAssay Description:Activity at hemagglutinin-tagged human CB1 receptor expressed in HEK293 cells assessed as effect on forskolin-induced cAMP accumulation after 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)