BDBM50346237 9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]azulen-6-one::CHEMBL1782170

SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1

InChI Key InChIKey=QSSHEITWSXIQFH-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50346237   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50346237(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human recombinant CDK2/cyclin A assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50346237(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of human recombinant CDK5/p25 assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50346237(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant CDK9/cyclin T expressed in insect cells assessed as incorporation of [gamma-33P]-ATP in to pRB fragment (773 to 928) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetCasein kinase I isoform alpha(Pig)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50346237(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of porcine brain CK1 assessed as incorporation of [gamma-33P]-ATP into RRKHAAIGpSAYSITA substrate after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50346237(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandPNGBDBM50346237(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli assessed as assessed as incorporation of [gamma-33P]-ATP into myelin bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50346237(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Plasmodium falciparum GSK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50346237(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK1/Cyclin B (unknown origin) in presence of gamma32P-ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50346237(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2/Cyclin A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50346237(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50346237(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50346237(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CLK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50346237(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed