BDBM50324210 (+/-)-(3SR,3aRS)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic Acid::(3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic Acid::CHEMBL1215331

SMILES OC(=O)c1ccc2C3=NN([C@@H](C4CCCC4)[C@H]3CCc2c1)c1ccc(C#N)c(Cl)c1

InChI Key InChIKey=XNULRSOGWPFPBL-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50324210   

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324210((3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-...)
Affinity DataIC50: 9nMAssay Description:Binding affinity to mineralocorticoid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324210((3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-...)
Affinity DataIC50: 9.20nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324210((3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-...)
Affinity DataIC50: 416nMAssay Description:Antagonist activity at progesterone receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324210((3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at glucocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324210((3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-...)
Affinity DataIC50: 8.91E+3nMAssay Description:Antagonist activity at androgen receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324210((3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at Gal4-tagged mineralocorticoid receptor expressed in human Huh7 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324210((3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at Gal4-tagged mineralocorticoid receptor expressed in human Huh7 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324210((3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-...)
Affinity DataIC50: 8.91E+3nMAssay Description:Antagonist activity at androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324210((3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324210((3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-...)
Affinity DataIC50: 416nMAssay Description:Antagonist activity at progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324210((3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at estrogen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50324210((3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of N-terminal polyhistidine-tagged human NSD2 expressed in baculovirus infected insect cell using SAM as substrate preincubated for 20 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM50324210((3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of N-terminal polyhistidine-tagged recombinant human NSD1 (1538 to 2696 residues) expressed in baculovirus infected insect cell using SAM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50324210((3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of N-terminal GST-fused recombinant human NSD3 (1021 to 1322 residues) expressed in Escherichia coli using SAM as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed