BDBM50275640 CHEMBL485967::N-(1-(naphthalen-1-yl)ethyl)-5-(2,2,2-trifluoroacetyl)thiophene-2-carboxamide

SMILES CC(NC(=O)c1ccc(s1)C(=O)C(F)(F)F)c1cccc2ccccc12

InChI Key InChIKey=ZAMUQCLCZMDPSF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50275640   

TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(N-(1-(naphthalen-1-yl)ethyl)-5-(2,2,2-trifluoroace...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of CYP2C9 in human hepatocytes in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(N-(1-(naphthalen-1-yl)ethyl)-5-(2,2,2-trifluoroace...)
Affinity DataIC50: 830nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(N-(1-(naphthalen-1-yl)ethyl)-5-(2,2,2-trifluoroace...)
Affinity DataIC50: 840nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(N-(1-(naphthalen-1-yl)ethyl)-5-(2,2,2-trifluoroace...)
Affinity DataIC50: 360nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(N-(1-(naphthalen-1-yl)ethyl)-5-(2,2,2-trifluoroace...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(N-(1-(naphthalen-1-yl)ethyl)-5-(2,2,2-trifluoroace...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2C9 in human hepatocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed