BDBM50271907 2-(2-chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,6-diamine::CHEMBL499345::N4-(3-bromophenyl)-6-(2-chlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

SMILES Nc1nc(Nc2cccc(Br)c2)c2cc(Cc3ccccc3Cl)[nH]c2n1

InChI Key InChIKey=ISXTVMIMVFTRIL-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50271907   

TargetInsulin receptor(Mouse)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50271907(2-(2-chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of insulin receptor-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50271907(2-(2-chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,...)
Affinity DataIC50: 4.31E+3nMAssay Description:Inhibition of EGFR expressed in human tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50271907(2-(2-chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,...)
Affinity DataIC50: 2.68E+4nMAssay Description:Inhibition of VEGFR1 expressed in human tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50271907(2-(2-chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,...)
Affinity DataIC50: 5.58E+3nMAssay Description:Inhibition of VEGFR2 expressed in human tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50271907(2-(2-chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PDGFRbeta expressed in human tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50271907(2-(2-chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,...)
Affinity DataIC50: 4.31E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50271907(2-(2-chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,...)
Affinity DataIC50: 2.68E+4nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50271907(2-(2-chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,...)
Affinity DataIC50: 5.58E+3nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50271907(2-(2-chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Mouse)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50271907(2-(2-chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,...)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of IGF1R-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed