BDBM50267951 CHEMBL4071408

SMILES Cc1cc(cc(C)c1N)C1=NN(CC2CC(Br)=NO2)C(=O)Cc2cc3OCCOc3cc12

InChI Key InChIKey=AUEHVKZCUPPOIK-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50267951   

TargetGlutamate receptor 2(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50267951(CHEMBL4071408)
Affinity DataKi:  5.00E+3nMAssay Description:Antagonist activity at closed state of GluA2Qflip isoform (unknown origin) expressed in HEK293 cells assessed as reduction in glutamate-induced curre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50267951(CHEMBL4071408)
Affinity DataKi:  6.40E+3nMAssay Description:Antagonist activity at open state of GluA1 (unknown origin) assessed as reduction in glutamate-induced current response in presence of 2 mM glutamateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetGlutamate receptor 4(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50267951(CHEMBL4071408)
Affinity DataKi:  7.40E+3nMAssay Description:Antagonist activity at closed state of GluA4 (unknown origin) assessed as reduction in glutamate-induced current response in presence of 100 uM gluta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetGlutamate receptor 4(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50267951(CHEMBL4071408)
Affinity DataKi:  1.14E+4nMAssay Description:Antagonist activity at open state of GluA4 (unknown origin) assessed as reduction in glutamate-induced current response in presence of 3 mM glutamateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50267951(CHEMBL4071408)
Affinity DataKi:  1.32E+4nMAssay Description:Antagonist activity at closed state of GluA1 (unknown origin) assessed as reduction in glutamate-induced current response in presence of 40 to 50 uM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetGlutamate receptor 3(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50267951(CHEMBL4071408)
Affinity DataKi:  1.39E+4nMAssay Description:Antagonist activity at open state of GluA3 (unknown origin) assessed as reduction in glutamate-induced current response in presence of 3 mM glutamateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed
TargetGlutamate receptor 3(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50267951(CHEMBL4071408)
Affinity DataKi:  2.78E+4nMAssay Description:Antagonist activity at closed state of GluA3 (unknown origin) assessed as reduction in glutamate-induced current response in presence of 100 uM gluta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMed