BDBM50254585 1-(2-((S)-3-(aminomethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)-4-chloro-5-methyl-N,N-diphenyl-1H-pyrazole-3-carboxamide::1-(2-{[(3S)-3-(aminomethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}phenyl)-4-chloro-5-methyl-N,N-diphenyl-1H-pyrazole-3-carboxamide::CHEMBL503454

SMILES Cc1c(c(nn1c2ccccc2C(=O)N3Cc4ccccc4C[C@H]3CN)C(=O)N(c5ccccc5)c6ccccc6)Cl

InChI Key InChIKey=MLZCQGFPFQDFLC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50254585   

TargetApoptosis regulator Bcl-2(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50254585(1-(2-((S)-3-(aminomethyl)-1,2,3,4-tetrahydroisoqui...)
Affinity DataIC50: 30nMAssay Description:Inhibition of GST fused Bcl-2 binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBcl2-associated agonist of cell death(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50254585(1-(2-((S)-3-(aminomethyl)-1,2,3,4-tetrahydroisoqui...)
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibition of GST fused Bcl-xL binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50254585(1-(2-((S)-3-(aminomethyl)-1,2,3,4-tetrahydroisoqui...)
Affinity DataIC50: 100nMAssay Description:Inhibition of GST fused Bcl-2 binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50254585(1-(2-((S)-3-(aminomethyl)-1,2,3,4-tetrahydroisoqui...)
Affinity DataIC50: 30nMAssay Description:Inhibition of Bcl2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed