BDBM50247802 CHEMBL474538::N4-(3-bromophenyl)-2-(naphthalen-1-ylmethyl)-1H-indole-4,6-diamine::N4-(3-bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

SMILES Nc1nc(Nc2cccc(Br)c2)c2cc(Cc3cccc4ccccc34)[nH]c2n1

InChI Key InChIKey=LAYLTVRTYJGALT-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50247802   

TargetVascular endothelial growth factor receptor 1(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50247802(N4-(3-bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-py...)
Affinity DataIC50: 1.92E+4nMAssay Description:Inhibition of VEGFR1 expressed in human tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50247802(N4-(3-bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-py...)
Affinity DataIC50: 5.08E+3nMAssay Description:Inhibition of VEGFR2 expressed in human tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50247802(N4-(3-bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PDGFRbeta expressed in human tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50247802(N4-(3-bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGFR expressed in human tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50247802(N4-(3-bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50247802(N4-(3-bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-py...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of EGFR tyrosine kinase activity in EGF-stimulated human A431 cells after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50247802(N4-(3-bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-py...)
Affinity DataIC50: 2.98E+4nMAssay Description:Inhibition of VEGFR2 tyrosine kinase activity in VEGF-stimulated human U251 cells after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50247802(N4-(3-bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-py...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of VEGFR1 tyrosine kinase activity in VEGF-stimulated human A498 cells after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50247802(N4-(3-bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-py...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of PDGFRbeta tyrosine kinase activity in PDGF-BB-stimulated human SF-539 cells after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50247802(N4-(3-bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50247802(N4-(3-bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-py...)
Affinity DataIC50: 1.92E+4nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50247802(N4-(3-bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-py...)
Affinity DataIC50: 5.08E+3nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50247802(N4-(3-bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-py...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed