BDBM50244236 CHEMBL500315::trans-4-(((4-tert-butylcyclohexyl)(5-(cyclopentyloxy)-1-methyl-1H-benzo[d]imidazol-2-yl)amino)methyl)-N-(1H-tetrazol-5-yl)benzamide

SMILES Cn1c(nc2cc(OC3CCCC3)ccc12)N(Cc1ccc(cc1)C(=O)Nc1nnn[nH]1)[C@H]1CC[C@@H](CC1)C(C)(C)C

InChI Key InChIKey=JODMSXNYADHQBE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50244236   

TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244236(trans-4-(((4-tert-butylcyclohexyl)(5-(cyclopentylo...)
Affinity DataIC50: 9nMAssay Description:Antagonist activity against human GCGR expressed in CHO cells assessed as glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPro-glucagon(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244236(trans-4-(((4-tert-butylcyclohexyl)(5-(cyclopentylo...)
Affinity DataIC50: 5.00E+3nMAssay Description:Binding affinity against human GLP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGastric inhibitory polypeptide(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244236(trans-4-(((4-tert-butylcyclohexyl)(5-(cyclopentylo...)
Affinity DataIC50: 2.00E+3nMAssay Description:Binding affinity against human GIPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244236(trans-4-(((4-tert-butylcyclohexyl)(5-(cyclopentylo...)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed