BDBM50236750 CHEMBL4070152

SMILES Fc1ccc(cc1)-c1c(cnc2cc(F)ccc12)S(=O)(=O)c1cc(F)cc(F)c1

InChI Key InChIKey=KMHZVMJTCPJKKY-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50236750   

TargetMetabotropic glutamate receptor 5(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50236750(CHEMBL4070152)
Affinity DataIC50: 25nMAssay Description:Negative allosteric modulation of human mGluR5a expressed in CHO cells assessed as reduction in DHPG-induced cytosolic Ca2+ influx after 10 to 20 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50236750(CHEMBL4070152)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat cerebrocortical membranes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2019
Entry Details Article
PubMed