BDBM50232347 CHEMBL4089840

SMILES O=C(COc1cccc2c1cc[nH]c2=O)c1ccccc1

InChI Key InChIKey=JJWMRRNGWSITSQ-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50232347   

TargetPoly [ADP-ribose] polymerase 1(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50232347(CHEMBL4089840)
Affinity DataIC50: 145nMAssay Description:Inhibition of recombinant human His6-tagged PARP1 autophosphorylation at ADP-ribosyltransferase domain by LC-MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50232347(CHEMBL4089840)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50232347(CHEMBL4089840)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50232347(CHEMBL4089840)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50232347(CHEMBL4089840)
Affinity DataIC50: 5.75E+3nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50232347(CHEMBL4089840)
Affinity DataIC50: 7.08E+3nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50232347(CHEMBL4089840)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50232347(CHEMBL4089840)
Affinity DataIC50: 3.09E+3nMAssay Description:Inhibition of recombinant human TNKS1 ADP-ribosyltransferase/sterile alpha motif domain expressed in Escherichia coli BL21(DE3) preincubated for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50232347(CHEMBL4089840)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of recombinant human TNKS1 ADP-ribosyltransferase/sterile alpha motif domain expressed in Escherichia coli BL21(DE3) preincubated for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50232347(CHEMBL4089840)
Affinity DataIC50: 145nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50232347(CHEMBL4089840)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50232347(CHEMBL4089840)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50232347(CHEMBL4089840)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50232347(CHEMBL4089840)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50232347(CHEMBL4089840)
Affinity DataIC50: 2.05E+4nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed