BDBM50226440 2-amino-6-(3,4-dichlorophenyl)-3,6-dimethyl-5,6-dihydro-3H-pyrimidin-4-one::CHEMBL239425

SMILES CN1C(N)=NC(C)(CC1=O)c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=XICGXUBMFPRVMO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50226440   

TargetBeta-secretase 1(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226440(2-amino-6-(3,4-dichlorophenyl)-3,6-dimethyl-5,6-di...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226440(2-amino-6-(3,4-dichlorophenyl)-3,6-dimethyl-5,6-di...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226440(2-amino-6-(3,4-dichlorophenyl)-3,6-dimethyl-5,6-di...)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed