BDBM50203538 (6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide::(6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxamide::CHEMBL375418

SMILES ONC(=O)[C@H]1CC2(CC2)CN[C@@H]1C(=O)N1CC=C(C1)c1ccccc1

InChI Key InChIKey=ZCDHAHOTIYZFKF-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50203538   

LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 23nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 77nMAssay Description:Binding affinity to MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 77nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 13nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 450nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 23nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 13nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 13nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 13nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 2.50E+3nMAssay Description:Binding affinity to MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 450nMAssay Description:Binding affinity to MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed