BDBM50162160 1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluoro-phenyl]-urea::1-[4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluoro-phenyl]-3-(2,4-difluoro-phenyl)-urea::CHEMBL179815

SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3F)c2cc1OC

InChI Key InChIKey=NZYLXYBIWNIAGH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50162160   

TargetVascular endothelial growth factor receptor 2(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162160(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 1nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162160(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 17nMAssay Description:Inhibition of platelet-derived growth factor receptor alpha in cell-intact assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM50162160(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 500nMAssay Description:Inhibition of EGFR expressed in DHER14 cells by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM50162160(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 500nMAssay Description:Inhibition of Her2 expressed in CSH12 cells by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM50162160(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of IGF1R by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed