BDBM50153847 3-Fluoro-N-{4-methyl-3-[4-(pyridin-2-ylmethoxy)-benzoylamino]-phenyl}-5-pyrrolidin-1-yl-benzamide::CHEMBL184712

SMILES Cc1ccc(NC(=O)c2cc(F)cc(c2)N2CCCC2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1

InChI Key InChIKey=PHMWPKDBVRDSTN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50153847   

TargetMitogen-activated protein kinase 14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153847(3-Fluoro-N-{4-methyl-3-[4-(pyridin-2-ylmethoxy)-be...)
Affinity DataIC50: 20nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153847(3-Fluoro-N-{4-methyl-3-[4-(pyridin-2-ylmethoxy)-be...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Renilla luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153847(3-Fluoro-N-{4-methyl-3-[4-(pyridin-2-ylmethoxy)-be...)
Affinity DataIC50: 450nMAssay Description:Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153847(3-Fluoro-N-{4-methyl-3-[4-(pyridin-2-ylmethoxy)-be...)
Affinity DataIC50: 25nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed