BDBM50095480 CHEMBL3590484::US10329294, Example 5

SMILES Cn1cc(NC(=O)c2cnn3ccc(NC4CCCCC4)nc23)c(n1)C(F)(F)F

InChI Key InChIKey=KJRJNZMCKDISMS-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50095480   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck

Curated by ChEMBL

LigandBDBM50095480(CHEMBL3590484 | US10329294, Example 5)Copy SMILESCopy InChI

Affinity DataIC50: 480nMAssay Description:Inhibition of human IRAK4 assessed as phosphorylation of fluorescent peptide substrate after 30 mins by fluorescent polarization readerMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/17/2016
Entry Details Article
Copy Entry DOIPubMed
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck

Curated by ChEMBL

LigandBDBM50095480(CHEMBL3590484 | US10329294, Example 5)Copy SMILESCopy InChI

Affinity DataIC50: 483nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/31/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL