BDBM50085020 ((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl)-phenyl-amine::(3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl)-phenyl-amine::CHEMBL2367916

SMILES [H][C@]12Cc3ccc(Nc4ccccc4)cc3[C@@](C)(CCN1CC1CC1)[C@H]2C

InChI Key InChIKey=FUMBLBJFVJXVBV-UHFFFAOYSA-N

Data  9 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50085020   

TargetMu-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50085020((3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataEC50:  15nMAssay Description:Incorporation of [35S]- GTPgammaS into CHO membranes expressing human Opioid receptor mu 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50085020((3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataEC50:  3.80nMAssay Description:Incorporation of [35S]GTP-gamma-S, into CHO membranes expressing human Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50085020((3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataKi:  0.540nMAssay Description:Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50085020((3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataKi:  0.540nMAssay Description:Binding affinity to displace radioligand [3H]U-69593 on Opioid receptor kappa 1 in guinea pig membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50085020((3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataKi:  0.540nMAssay Description:Displacement of [3H]U69,593 from KOR in guinea pig brain membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50085020((3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50085020((3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to displace radioligand [3H]DAMGO on Opioid receptor mu 1 in guinea pig membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50085020((3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]DAMGO from MOR in guinea pig brain membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50085020((3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity towards Opioid receptor delta 1 from guinea pig brain using [3H]naltrindole as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50085020((3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity to displace radioligand [3H]naltrindole on Opioid receptor delta 1 in guinea pig membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetOpioid receptor delta 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50085020((3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hex...)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H]Naltrindole from DOR in guinea pig brain membranes after 3 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed