BDBM50072833 CHEMBL3410060::US11208696, Example 2

SMILES CC(C)CNc1nccn2c(cnc12)-c1ccc(cc1)C(=O)NC1CC1

InChI Key InChIKey=QTOFVYOMOKYCEQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50072833   

TargetDual specificity protein kinase TTK(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50072833(CHEMBL3410060 | US11208696, Example 2)
Affinity DataIC50: 55nMAssay Description:Inhibition of Mps1 (unknown origin)-mediated p38 MAPK phosphorylation after 90 mins by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2016
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50072833(CHEMBL3410060 | US11208696, Example 2)
Affinity DataIC50: 14nMAssay Description:Inhibition of human TTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50072833(CHEMBL3410060 | US11208696, Example 2)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50072833(CHEMBL3410060 | US11208696, Example 2)
Affinity DataIC50: 10nMAssay Description:Inhibition of GST-tagged recombinant human MPS1 expressed in baculovirus expression system using biotin-Ahx-PWDPDDADITEILG as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50072833(CHEMBL3410060 | US11208696, Example 2)
Affinity DataIC50: 230nMAssay Description:Inhibition of GST-tagged recombinant human MPS1 expressed in baculovirus expression system using biotin-Ahx-PWDPDDADITEILG as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50072833(CHEMBL3410060 | US11208696, Example 2)
Affinity DataIC50: 670nMAssay Description:Inhibition of MPS1 in human HeLa cells assessed as reduction in spindle assembly checkpoint incubated for 4 hrs by p-histone H3/Hoechst 33342 stainin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50072833(CHEMBL3410060 | US11208696, Example 2)
Affinity DataIC50: 4.10nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetMacrophage-expressed gene 1 protein(Mus musculus)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50072833(CHEMBL3410060 | US11208696, Example 2)
Affinity DataIC50: 55nMAssay Description:Inhibition of mouse MPS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed