BDBM50052030 (R)-Cyclopentyl-[4-(quinolin-2-ylmethoxy)-phenyl]-acetic acid::CHEMBL88712::Cyclopentyl-[4-(quinolin-2-ylmethoxy)-phenyl]-acetic acid

SMILES c1ccc2c(c1)ccc(n2)COc3ccc(cc3)[C@@H](C4CCCC4)C(=O)O

InChI Key InChIKey=ZEYYDOLCHFETHQ-UHFFFAOYSA-N

Data  3 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50052030   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50052030((R)-Cyclopentyl-[4-(quinolin-2-ylmethoxy)-phenyl]-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50052030((R)-Cyclopentyl-[4-(quinolin-2-ylmethoxy)-phenyl]-...)
Affinity DataIC50: 220nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as inhibition of LTB4 formation preincubated for 5 mins followed by calcium ionophore A23187 additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50052030((R)-Cyclopentyl-[4-(quinolin-2-ylmethoxy)-phenyl]-...)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of 5-LOX in human whole blood assessed as inhibition of LTB4 formation preincubated for 10 mins followed by calcium ionophore A23187 addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed