BDBM50016250 CHEMBL81925

SMILES CN1C2N(CCc3c2[nH]c2ccccc32)C(=O)c2ccccc12

InChI Key InChIKey=TXDUTHBFYKGSAH-UHFFFAOYSA-N

Data  5 IC50  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50016250   

TargetCholinesterase(Horse)
University of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50016250(CHEMBL81925)
Affinity DataIC50: 4.62E+3nMAssay Description:Inhibition of equine serum BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
University of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50016250(CHEMBL81925)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
LigandPNGBDBM50016250(CHEMBL81925)
Affinity DataEC50:  860nMAssay Description:Agonist activity at rat TRPV1 expressed in CHO cells assessed as induction of 45Ca2+ uptake measured after 5 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
LigandPNGBDBM50016250(CHEMBL81925)
Affinity DataEC50:  600nMAssay Description:Agonist activity at rat TRPV1 channel expressed in HEK293 cells assessed as induction of channel current at -60 mV holding potential by whole-cell pa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
LigandPNGBDBM50016250(CHEMBL81925)
Affinity DataEC50:  860nMAssay Description:Agonist activity at rat TRPV1 expressed in CHO cells assessed as induction of 45Ca2+ uptake measured after 5 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
LigandPNGBDBM50016250(CHEMBL81925)
Affinity DataEC50:  100nMAssay Description:Partial antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as capsaicin EC50 for induction of channel current at 0.1 uM at -60 mV ho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
LigandPNGBDBM50016250(CHEMBL81925)
Affinity DataEC50:  180nMAssay Description:Partial antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as capsaicin EC50 for induction of channel current at 0.6 uM at -60 mV ho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
LigandPNGBDBM50016250(CHEMBL81925)
Affinity DataEC50:  2.38E+3nMAssay Description:Partial antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as capsaicin EC50 for induction of channel current at 10 uM at -60 mV hol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
LigandPNGBDBM50016250(CHEMBL81925)
Affinity DataIC50: 440nMAssay Description:Partial antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced inward current at -60 mV holding poten...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50016250(CHEMBL81925)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 incubated for 15 mins using [3H]-cGMP as substrate by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50016250(CHEMBL81925)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of human PDE6C (2-854 residues) expressed in Sf9 cells incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50016250(CHEMBL81925)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed