BDBM488039 N-(4-(4- (Cyclopropylmethyl) piperazin-1-yl)phenyl)- 4-(1-ethyl-3-(pyridin- 3-yl)-1H-pyrazol-4- yl)pyrimidin-2-amine::US10954216, Example 33

SMILES CCn1cc(c(n1)-c1cccnc1)-c1ccnc(Nc2ccc(cc2)N2CCN(CC3CC3)CC2)n1

InChI Key InChIKey=ZFVHCGCHVVRNAH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 488039   

TargetActivin receptor type-1 [R206H](Human)
Riken

US Patent
LigandPNGBDBM488039(N-(4-(4- (Cyclopropylmethyl) piperazin-1-yl)phenyl...)
Affinity DataIC50: 5.70nMAssay Description:R206H: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 (R206H) is as follows.In a buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent

TargetActivin receptor type-1(Human)
Riken

US Patent
LigandPNGBDBM488039(N-(4-(4- (Cyclopropylmethyl) piperazin-1-yl)phenyl...)
Affinity DataIC50: 6.10nMAssay Description:TABLE 5: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 is as follows. In a buffer sol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent