BDBM451765 3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin-6- yl)pyridin-3- yl)benzenesulfonamide::US10710978, Compound I-71

SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)S(N)(=O)=O

InChI Key InChIKey=MKDAADZCSDCLHY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 451765   

TargetSerine/threonine-protein kinase 4(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451765(3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Affinity DataIC50: 550nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase 3(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451765(3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase 24(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451765(3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase 26(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM451765(3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
Go to US Patent