BDBM433290 3-(4-(aminomethyl)-4- methylpiperidin-1-yl)-6- ((2,3- dichlorophenyl)thio) pyrazin-2(1H)-one::US10561655, Compound 2

SMILES CC1(CN)CCN(CC1)c1ncc(Sc2cccc(Cl)c2Cl)[nH]c1=O

InChI Key InChIKey=BDVBRXRTCUTPGF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 433290   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Synblia Therapeutics

US Patent
LigandPNGBDBM433290(US10561655, Compound 2 | 3-(4-(aminomethyl)-4- met...)
Affinity DataIC50: 50nMAssay Description:IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Synblia Therapeutics

US Patent
LigandPNGBDBM433290(US10561655, Compound 2 | 3-(4-(aminomethyl)-4- met...)
Affinity DataIC50: 50nMAssay Description:Allosteric inhibition of SHP2 (unknown origin) using DiFMUP as substrate preincubated for 60 mins in presence of activating peptide IRS-1 followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed