BDBM430357 2-fluoro-N-[3- (hydroxymethyl)-6- phenylpyrazolo[1,5- a]pyridin-7-yl]-5-(1- methyl-1H-pyrazol-3-yl)-4- (trifluoromethyl)benzamide::US10556900, Compound 39

SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2c(ccc3c(CO)cnn23)-c2ccccc2)c(F)cc1C(F)(F)F

InChI Key InChIKey=NZEMBUDDHUVSNR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 430357   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM430357(2-fluoro-N-[3- (hydroxymethyl)-6- phenylpyrazolo[1...)
Affinity DataIC50: 0.330nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent