BDBM427056 (3R)-3-(4-chlorophenyl)-2-[(1S)-1-(4-chlorophenyl)ethyl]-6-(2-hydroxy-1-methoxypropan-2-yl)-3-{[1-(hydroxymethyl)cyclopropyl]methoxy}-2,3-dihydro-1H-isoindol-1-one::US10544132, Example 10::US10981898, Example 10

SMILES COC[C@](C)(O)c1ccc2c(c1)C(=O)N([C@@H](C)c1ccc(Cl)cc1)[C@@]2(OCC1(CO)CC1)c1ccc(Cl)cc1

InChI Key InChIKey=UIFBZUZURMPJLE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 427056   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM427056((3R)-3-(4-chlorophenyl)-2-[(1S)-1-(4-chlorophenyl)...)
Affinity DataIC50: 3.70nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

LigandPNGBDBM427056((3R)-3-(4-chlorophenyl)-2-[(1S)-1-(4-chlorophenyl)...)
Affinity DataIC50: 3.70nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent