BDBM418851 N-[3-({[2-({4-[(1R)-1- aminoethyl]phenyl}amino)-5- (trifluoromethyl)pyrimidin-4- yl]amino}methyl)pyrazin-2-yl]-N- methylmethane-sulfonamide (351), hydrochloride salt::US10450297, Example 351::US10450297, Example 355

SMILES C[C@H](N)c1ccc(Nc2ncc(c(NCc3nccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1

InChI Key InChIKey=YWHNGLQEIOWZHQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 418851   

TargetFocal adhesion kinase 1 [410-689](Human)
Pfizer

US Patent
LigandPNGBDBM418851(US10450297, Example 351 | N-[3-({[2-({4-[(1R)-1- a...)
Affinity DataIC50: 0.616nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
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TargetFocal adhesion kinase 1 [410-689](Human)
Pfizer

US Patent
LigandPNGBDBM418851(US10450297, Example 351 | N-[3-({[2-({4-[(1R)-1- a...)
Affinity DataIC50: 0.595nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
Go to US Patent