BDBM406750 N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]-2-(pyrrolidin-1-yl)acetamide::US10336761, Example 33

SMILES FC(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)CN3CCCC3)c2)c2cccn2n1

InChI Key InChIKey=FMHARFPNLLFDTG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406750   

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406750(N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2...)
Affinity DataIC50: 0.900nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTGF-beta receptor type-2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406750(N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2...)
Affinity DataIC50: 1.50E+4nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent