BDBM315188 (3R/S)-3-(3-{[(2R/S)-2-Cyclobutyl-2-{4-[5-(trifluoromethyl)pyridin-3-yl]phenyl}acetyl]amino}-2-methylphenyl)butanoic acid::US10172814, Example 130::US10172814, Example 131::US10172814, Example 132::US10172814, Example 133::US10172814, Example 134

SMILES CC(CC(O)=O)c1cccc(NC(=O)C(C2CCC2)c2ccc(cc2)-c2cncc(c2)C(F)(F)F)c1C

InChI Key InChIKey=QTYZIHUQYLPTEJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 315188   

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM315188((3R/S)-3-(3-{[(2R/S)-2-Cyclobutyl-2-{4-[5-(trifluo...)
Affinity DataIC50: 72.3nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM315188((3R/S)-3-(3-{[(2R/S)-2-Cyclobutyl-2-{4-[5-(trifluo...)
Affinity DataIC50: 1.02E+3nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM315188((3R/S)-3-(3-{[(2R/S)-2-Cyclobutyl-2-{4-[5-(trifluo...)
Affinity DataIC50: 38.6nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM315188((3R/S)-3-(3-{[(2R/S)-2-Cyclobutyl-2-{4-[5-(trifluo...)
Affinity DataIC50: 1.77E+3nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM315188((3R/S)-3-(3-{[(2R/S)-2-Cyclobutyl-2-{4-[5-(trifluo...)
Affinity DataIC50: 7.59nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent