BDBM284734 US10023575, Example 25::US10479794, Example 25::US10875867, Example 25

SMILES Cc1nn2cc(cnc2c1C(=O)NC1(CCOCC1)c1ccc(nc1)C(F)(F)F)C1CC1

InChI Key InChIKey=ZQCNVEVKLWTZEE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 284734   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM284734(US10023575, Example 25 | US10479794, Example 25 | ...)
Affinity DataIC50: 88nMT: 2°CAssay Description:All reactions were performed in 384 well plates, Perkin Elmer black optiplates and IMAP reaction buffer with 0.1% Tween20 (kit component)Compounds we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
Go to US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM284734(US10023575, Example 25 | US10479794, Example 25 | ...)
Affinity DataIC50: 9.07E+3nMT: 2°CAssay Description:All reactions were performed in 384 well plates, Perkin Elmer black optiplates and IMAP reaction buffer with 0.1% Tween20 (kit component)Compounds we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM284734(US10023575, Example 25 | US10479794, Example 25 | ...)
Affinity DataIC50: 88nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2020
Entry Details
Go to US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM284734(US10023575, Example 25 | US10479794, Example 25 | ...)
Affinity DataIC50: 9.07E+3nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2020
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM284734(US10023575, Example 25 | US10479794, Example 25 | ...)
Affinity DataIC50: 88nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM284734(US10023575, Example 25 | US10479794, Example 25 | ...)
Affinity DataIC50: 9.07E+3nMAssay Description:The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent