BDBM258598 US9493490, Example 10::US9493490, G

SMILES C[C@@H](N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1

InChI Key InChIKey=LKHWQSZVOZRQIZ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 258598   

TargetGlutathione S-transferase P/Rho-associated protein kinase 1 [1-535](Human)
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258598(US9493490, Example 10 | US9493490, G)
Affinity DataIC50: 170nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetGlutathione S-transferase P/Rho-associated protein kinase 2 [5-554](Human)
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258598(US9493490, Example 10 | US9493490, G)
Affinity DataIC50: 170nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258598(US9493490, Example 10 | US9493490, G)
Affinity DataIC50: 10.9nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetBeta-adrenergic receptor kinase 1(Human)
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258598(US9493490, Example 10 | US9493490, G)
Affinity DataIC50: 13.9nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258598(US9493490, Example 10 | US9493490, G)
Affinity DataIC50: 1.79nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258598(US9493490, Example 10 | US9493490, G)
Affinity DataIC50: 15.6nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetRibosomal protein S6 kinase alpha-1(Human)
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258598(US9493490, Example 10 | US9493490, G)
Affinity DataIC50: 3.62nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent