BDBM25285 (1-hydroxy-1-phosphonododecyl)phosphonic acid::CHEMBL416301::bisphosphonate, 11

SMILES CCCCCCCCCCCC(O)(P(=O)(O)O)P(=O)(O)O

InChI Key InChIKey=KKVZONPEMODBBG-UHFFFAOYSA-N

Data  1 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 25285   

TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25285(CHEMBL416301 | (1-hydroxy-1-phosphonododecyl)phosp...)
Affinity DataIC50: 2.69E+3nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2008
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25285(CHEMBL416301 | (1-hydroxy-1-phosphonododecyl)phosp...)
Affinity DataIC50: 920nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25285(CHEMBL416301 | (1-hydroxy-1-phosphonododecyl)phosp...)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyprenyl synthetase family protein(Leishmania donovani)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25285(CHEMBL416301 | (1-hydroxy-1-phosphonododecyl)phosp...)
Affinity DataIC50: 7.75E+3nMAssay Description:Inhibitory activity against Leishmania major Farnesyl diphosphate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25285(CHEMBL416301 | (1-hydroxy-1-phosphonododecyl)phosp...)
Affinity DataIC50: 7.76E+3nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME (M)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25285(CHEMBL416301 | (1-hydroxy-1-phosphonododecyl)phosp...)
Affinity DataKi:  740nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed