BDBM22168 (1S)-3-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}piperazin-1-yl)-1-phenylpropan-1-ol::CHEMBL26478::GBR 12935 Analogue, (S)-3

SMILES O[C@@H](CCN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccccc1

InChI Key InChIKey=FRNMVZXBCHKPGE-UHFFFAOYSA-N

Data  6 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 22168   

TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22168(CHEMBL26478 | (1S)-3-(4-{2-[bis(4-fluorophenyl)met...)
Affinity DataIC50: 178nMAssay Description:Reuptake inhibition of [3H]-5-HT (5-HT) in rat.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22168(CHEMBL26478 | (1S)-3-(4-{2-[bis(4-fluorophenyl)met...)
Affinity DataIC50: 3.60nMAssay Description:Reuptake inhibition of [3H]-labeled dopamine (DA) in rat.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22168(CHEMBL26478 | (1S)-3-(4-{2-[bis(4-fluorophenyl)met...)
Affinity DataKi:  4.40nM ΔG°:  -10.6kcal/molepH: 7.4 T: 2°CAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22168(CHEMBL26478 | (1S)-3-(4-{2-[bis(4-fluorophenyl)met...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity against dopamine transporter labelled with [125I]- RTI-55 in rat.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22168(CHEMBL26478 | (1S)-3-(4-{2-[bis(4-fluorophenyl)met...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity for dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22168(CHEMBL26478 | (1S)-3-(4-{2-[bis(4-fluorophenyl)met...)
Affinity DataKi:  135nM ΔG°:  -8.71kcal/molepH: 7.4 T: 2°CAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22168(CHEMBL26478 | (1S)-3-(4-{2-[bis(4-fluorophenyl)met...)
Affinity DataKi:  135nMAssay Description:Binding affinity against Serotonin transporter (SERT) labelled with [125I]RTI-55 in rat.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM22168(CHEMBL26478 | (1S)-3-(4-{2-[bis(4-fluorophenyl)met...)
Affinity DataKi:  135nMAssay Description:Binding affinity for serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed