BDBM18665 (2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide::BMC185567 S-4::CHEMBL125236::Nonsteroidal AR Ligand, S-6

SMILES CC(=O)Nc1ccc(OC[C@](C)(O)C(=O)Nc2ccc(c(c2)C(F)(F)F)[N+]([O-])=O)cc1

InChI Key InChIKey=YVXVTLGIDOACBJ-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 18665   

TargetAndrogen receptor(Rat)
University of Tennessee At Memphis

LigandPNGBDBM18665(CHEMBL125236 | (2S)-3-(4-acetamidophenoxy)-2-hydro...)
Affinity DataKi:  3.98nM ΔG°:  -10.6kcal/molepH: 7.4 T: 2°CAssay Description:The Ki values were determined by the application of the Cheng-Prusoff equation: Ki = (IC50 x Kd)/(Kd+[L]) where [L] is the concentration of [3H]MIB (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Rat)
University of Tennessee At Memphis

LigandPNGBDBM18665(CHEMBL125236 | (2S)-3-(4-acetamidophenoxy)-2-hydro...)
Affinity DataKi:  4nM ΔG°:  -10.6kcal/molepH: 7.4 T: 2°CAssay Description:The Ki values were determined by the application of the Cheng-Prusoff equation: Ki = (IC50 x Kd)/(Kd+[L]) where [L] is the concentration of [3H]MIB (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Gtx

Curated by ChEMBL
LigandPNGBDBM18665(CHEMBL125236 | (2S)-3-(4-acetamidophenoxy)-2-hydro...)
Affinity DataKi:  4nMAssay Description:Agonist activity at androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Gtx

Curated by ChEMBL
LigandPNGBDBM18665(CHEMBL125236 | (2S)-3-(4-acetamidophenoxy)-2-hydro...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]mibolerone from Androgen receptor (unknown origin) measured by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed