BDBM161450 US10124003, Ex. Compound 63::US10835536, Ex. Comp 63::US10894048, Ex Comp 62::US9108973, 63

SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN2CC[C@@H](O)C2)c2ncnc(N)c12

InChI Key InChIKey=YTDWYXQAKOWNAV-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 161450   

TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161450(US9108973, 63 | US10124003, Ex. Compound 63 | US10...)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2016
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161450(US9108973, 63 | US10124003, Ex. Compound 63 | US10...)
Affinity DataIC50: 1nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161450(US9108973, 63 | US10124003, Ex. Compound 63 | US10...)
Affinity DataIC50: 1nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161450(US9108973, 63 | US10124003, Ex. Compound 63 | US10...)
Affinity DataIC50: 1nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161450(US9108973, 63 | US10124003, Ex. Compound 63 | US10...)
Affinity DataIC50: 3.10nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR1 kinase activity, a biotinylated peptide (biotin-EEPLYW...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161450(US9108973, 63 | US10124003, Ex. Compound 63 | US10...)
Affinity DataIC50: 0.700nMAssay Description:The inhibitory effect of the compounds on FGFR3 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161450(US9108973, 63 | US10124003, Ex. Compound 63 | US10...)
Affinity DataIC50: 19nMAssay Description:The inhibitory effect of the compounds on FGFR4 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent