BDBM134283 US8853228, F26M

SMILES COc1cc(ccc1C(C)C#Cc1c(C)nc(N)nc1N)-c1c(C)cccc1C

InChI Key InChIKey=YFKWCAHJYXKVLT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 134283   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut

US Patent
LigandPNGBDBM134283(US8853228, F26M)
Affinity DataIC50: 7.40nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
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TargetDihydrofolate reductase(Human)
University of Connecticut

US Patent
LigandPNGBDBM134283(US8853228, F26M)
Affinity DataIC50: 3.37E+3nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
Go to US Patent