BDBM50235385 APD-811::Ralinepag

SMILES OC(=O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1

InChI Key InChIKey=NPDKXVKJRHPDQT-UHFFFAOYSA-N

Data  7 KI  8 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50235385   

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataIC50: 38nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataEC50:  850nMAssay Description:Agonist activity at recombinant human DP1 receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataEC50:  8.5nMAssay Description:Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Rat)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataEC50:  530nMAssay Description:Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstacyclin receptor(Rat)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataKi:  76nMAssay Description:Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataKi:  143nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP3v6 receptor expressed in HEK293 cell membranes incubated for 1 hr by top count scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataKi:  610nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataKi:  678nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in rat chem-1 cell membranes incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataKi:  2.60E+3nMAssay Description:Displacement of [3H]-PGD2 from recombinant human DP1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235385(APD-811 | Ralinepag)
Affinity DataKi:  9.60E+3nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP1 receptor expressed in HEK293 cell membranes incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2019
Entry Details Article
PubMed